Ivory isn't THAT fragile, but the stresspoints on a revolver frame (mostly the shoulders at the top, and the "pin" that secures the bottom of the panels) can get shocked pretty hard upon recoil from even .357's or .44 specials. I had a pair that I thought fit quite well on a .44 spec and I got some light stress cracks at the top, and chunk out of the bottom of the grip at the pin hole (took out a chunk at the bottom directly below the pin, barely noticeable). I'd still recommend synthetic if being fired, or the real stuff for display or firing light loads.