Lyman did some pressure testing using a modified cap and ball revolver. 37 grains of powder 3f and 4f resulted in 7,420 and 7,940 LUP using Goex powders.
C&H 4f actually produced lower pressure than Goex 3f, 6820 LUP.
Looking at these pressures and considering the fact that a Ruger Old Army is essentially a Super Blackhawk converted to a cap and ball revolver, I'm not worried about it blowing up with 4f.
It's just the next smaller granulation of black powder, not dynamite.