Advice for Shooting the 45LC/.410 Pepperbox
I've had quite a bit of experience shooting this caliber type. I've owned the Model 4 & 6 American Derringers, the equivalent Bond derringer, and the Lenid double barrel model. I've found that shooting the 2.5 and 3 inch defensive load .410 shotshells (00 buck, 000 buck, #4 shot and the new Winchester PDX-1) can leave you hands hurting (or bleeding from the recoil). The use of the 45LC (actually just "Colt") is a pretty demanding load and I found that the smaller .45 Schofield round is easier on the hand and has better ballestics. I was able to hit the target (up to 25 feet) with fairly good consistency, but never better than 4 to 5 inch groups. The Schofield round is not as easy to find, but Cabelas and other on-line sources has them readily available. The cartridge is simply the short version of the Colt. It uses the same bullet, but a smaller powder charge, ergo... less of a kick. I think it has about the same feel or recoil of a standard .45ACP. In a pinch, I've actually used a .45ACP round with a small o-ring washer fitted over the end of the cartridge (close to the primer end). The washer fits naturally in the recessed area of the cartridge. This kept the bullet in place within the receiver, but I wouldn't recommend this (no advice) for anyone else. I took the risk and thankfully it didn't blow up in my hand. There is normally quite a lot of play or headspace in a small derringer, so this just worked out. Most older derringers have a tendency to rattle a bit unless a cartridge is in place to take up that space.
The new Lenid Pepperbox is roughly made with a blend of composite lower and steel barrel. The double barrel model I had for a short time required some much needed honing ("melting" of the sharp production edges) followed by a nice Duracoat finish. A larger grip would also be a necessity, if you have a manly hand and want to keep some skin after firing it. The inside of your thumb and the meaty portion between the thumb and index finger can take a real beating. Therefore, a shooting glove is "highly" recommended!