If you plan on reloading for your Glock 22, just follow some precautions and all shall be well...
1) As the others have stated, do not use soft unjacketed lead bullets. Pay the extra $$$ for plated or hard jacketed bullets, and you won't regret it.
If you insist on using unjacketed lead, make sure that it is hard enough to resist getting chewed up by the polygonal rifling. Soft lead bullets that work fine in a conventionally rifled barrel will end up turning your Glock barrel into a smoothbore barrel.
2) Load conservatively. Stick with the lower end of the spectrum.
3) Carefully police your brass. If there are any amounts of unusual bulging, toss it out. Because of the throated factory barrel, you get ironclad reliability with a wide range of ammo, but at the same time, the 6 o'clock area of the brass casing gets subjected to more wear and tear.
Or...
You could buy an aftermarket barrel and load for your Glock as you would any other brand. The reason for the aftermarket barrel is for the additional chamber support, especially at the 6 o'clock position, and also because the conventional rifling allows you to shoot softer alloys of unjacketed lead. This is the safest way to reload for it.
What most of us do is to use the aftermarket barrel for plinking purposes (saves lots of wear and tear on the brass), and the factory barrel for defensive use.
Barsto and Jarvis have my vote as the best aftermarket barrel, followed very closely by Briley, KKM, and Olympic Arms.
http://www.barsto.com
http://www.jarvis-custom.com
http://www.briley.com
http://www.kkmprecision.com
http://www.olyarms.com
http://www.lonewolfdist.com
Lone Wolf carries Jarvis, KKM, and Federal Arms barrels.
The Olympic Arms barrels are the best bang for the buck, since they only cost 114 + shipping.