Mine is zero'd at 100 because the majority of my shots are right there, or closer. I also use that round for turkey, so I've got to know exactly where that bullet is going. It's not hard to make the adjustment for 200-300 yds. each gun is a little different, so my advice is go to the range and practice. The main thing isn't so much where your gun is statistically. It's that you know where to aim for a particular POI. A little practice, and you'll have it down pat, regardless of where you decide to zero your gun. Also, here's another tidbit of info...Zero your gun where you expect the majority of your shots to be...The less you have to think in a hunting situation, the better off you are going to be....and the more accurate you are going to be.