My gun safe's are in my home office/work space. If I'm home during the day, particularly if in the office, I open the doors to the safe's for several hours per day. It helps air circulate inside and helps reduce moisture. I close them at bed time, when I leave, or if company comes over. It is just my wife and I at home now. Kids are grown and out of the house.
I may, or may not get anything out. It just depends, but I have a large window that opens to a wooded area behind the house. It wouldn't be unusual for me to get in a little dry fire practice on squirrels, or birds outside the window with one of the rifles.
I voted 5 times/ week. Probably about average although there may be times where I may go a week or longer without opening the doors, and other times where they are open every day for weeks.