I loaded up some .45 Colt using 200 grain RNFP cast lead bullets, HS-6, starline brass and CCI primers and did a light roll crimp right at the top of the cannelure. It turned out to be a very accurate load. I repeated the same load for today's shooting and it was very inconsistent. I looked closely at the unfired cartridges and noticed that I didn't get the bullets seated as deep as the first load and a little more of the cannelure was visible. The bullets shot low and a few shot very low. I'm certainly no marksman, but I don't string bullets vertically as bad as these were. Could improper seating depth cause such inconsistencies?