If you want some kick, shoot a 350gr @2200fps out of a Ruger No.3!
I'm 6' and 250lbs+ (more plus than I like to admit) and this load walks me back a step when I shoot it. Won't shoot it from a bench, and NEVER prone!
Bought the gun nearly 30 years ago, and 50rnds of Hornday 350gr on top of a stiff charge of IMR 4227. Still have 11 of those rounds left!!!!
Got a .458 Win later, thinking I wanted more. Turns out, I didn't want more, once I had it.
Shoots great (and much more comfortable) with lighter loads, and kills dead everything that walks. So I don't bother with the uber monster loads anymore.
One word of caution, if you want hot loads, choose the right bullet. The Speer 400gr JSP isn't it. Designed to expand at much lower speeds, when you get that bullet up to 1800fps (or more,
) it turns into a grenade. At high speed, it acts like a varmint bullet. Not really suitable for big game anymore.
The Hornady 350gr and some others are built to take the higher speeds without blowing up on impact.