Having used these in 30 Carb. I'll toss in my $.02 on this subject.
Aside from having issues with them feeding in my gun due to their profile, you have other considerations.
First and Foremost..they measure .309....not .308; if you have a tighter chamber you will have issues chambering them. I know two people with 30 carb.s that they wouldn't chamber in w/o forcing the bolt home the last bit. The brass was being pinched.
Second, at 2200 fps, they were already at the explosive expansion point.
Third, the Speer 110 varminter HP has a 2900 fps limit... I would drop this to 2400 for the Hornady. The Speer was made for the 30 Carb., the Hornady was made for the Tok. and Mauser.
If you want to go this particular route, use the Speer 110 varminter HP part # 1835. There is data for it, the limits are known, and it will do what you want. At 30 carb. velocities, I recovered one that went end to end through a 25 lb. watermelon. It expanded to over .45, retained weight was 78 gr., the melon was blown to pieces, and the inside of most of the melon was turned to goo. The slug was stopped by the pine tree behind it. Not the most scientific test but a real eye opener. I REALLY want to try some in Gel.