HD will always be a stress event. If you consider simplicity and some other very important points, the sp101 or other DA revolver will be your best choice.
When a crisis comes, a person picks up a loaded gun, aims, and pulls the trigger. there are 6 rounds available, and no round on the market can claim that it is significantly better at disabling a man than a .357 load.
If I'm some night dragged out of sleep and confronted with an intruder, I'm probably going to die. I'm barely able to move my fingers. My only hope for survival is that my .357 is loaded, in a drawer, by my bed, and after thousands of rounds through it and other pistols, I could probably fire it in my sleep. I probably couldn't even get the safety off of my browning and cock it.
Thank god my wife will be there telling me what to do.