Max,
Your premise about slow powders for rifles is in error. The reason for a .45 Auto cartridge using fast powders are two: The first is the bullets have lower sectional densities, so they are easy for pressure to accelerate forward. The second is the bullet doesn't have to move very far forward before the total volume behind its base has doubled the amount of room the powder is burning it. It's only about a third of an inch for .45 Auto hardball, where a typical .30-06, for example, has to move about ten times that far to double the volume of the powder burning space behind it. So the .45 Auto bullets scoot forward easily and the volume keeps doubling rapidly. It takes a fast powder to make gas fast enough to keep up with the bullet and still continue to grow the pressure until it reaches its peak. If you were to try to use .30-06 powder in it the bullet would grow the space so fast the powder would fizzle and the bullet would be left stuck in the barrel.
Note also, the rifle would not be chambered for .45 Auto if it didn't work with commercial ammunition, all of which is loaded for pistol using fast powders. That will be what works with this gun. Probably the slowest powders that would be usable are Power Pistol and HS-6, which are used by some practical competitors to raise the power factor of their loads. Anything slower, like 296, will be likely to squib out because you can't fit enough in the .45 Auto load to reach a pressure it works at well (good thing, as those are magnum revolver pressures most .45 Auto firearms won't tolerate). So its performance will be very poor and it will burn very dirty and incompletely, and you may get a bullet stuck in the bore.