I use an App called Strelok+. It is a ballistic calculator among other things. You can program your rifle, scope, cartridge and reticle in it and it will get you into the ball park or better of where you bullet will be under a given range and conditions. It's not perfect, but it saves a lot of bullets, time, and money getting you real close.
The MPBR really depends on the size of the object that you are shooting at. Strelok will give you what it refers to as a most reasonable distance for the setup that you have. You can also program the reticle that you have and look at what your holdover should look like in your particular reticle.
I use it a lot for long range hunting, and I have NEVER missed with it. It is very accurate. You just have to know the velocity an BC of the projectile that you are using.
You can also set up multiple rifle, scope, cartridge combinations with it.
The last deer that I shot in December was at 435 yards. Using Strelok, with my rifle zeroed at 273, It gave me the number of clicks to come up and windage. Bang, right behind the shoulder. Deer ran 15yards and piled up.
That was with the Browning A bolt 25-06 with the 100 grain Scirocco.
Its pretty cool, and I like it and find it to be very accurate.
BTW 25-06 is a super cartridge. Very impressive kills on deer!