Compensate for it or take an advanced course in shooting. I'm not sure about the rest of the Forum, but each of my revolvers shoot abit different.. So I went to the range and put about 50 rounds of ammo through each revolvver and made notes as to which shot dead on and which shot slightly to upper left or lower right. I'm left handed but I realized that in a stress moment that the odds that I would remember about this wasn't too good. So, I carry one revolver always and this one shoots dead center where I am aiming.
Since I've never been in a life or death situation(never hope to), I'm about as prepared as I'll ever be and that's probably not enough.