Back in the old days when I lived in Ohio,,the longest shot I can ever remember is about 250yrds. just because thats how the farms are layed out where I lived.
I have a Ruger VBZ in 223,,the one I have is the first year production,,hammer forged 26" barrel and a blue reciever,,,this gun will do 1/2-3/8 groups all day long at 200yrds,,with the loads I have worked up for it,,53gr. hornady match hollow point
it has a truck load of whistle pigs under its belt,,,several coyotes and foxes
the gun is zeroed at 175,,and i have a target that has 5 holes touching at that zero,,this gun is heavy,,in the 10# range IIRC,,you never lose the target in the scope ,, recoil is hardly noticed
223 is cheap and deadly,, and fun because it is cheap,,easy on barrels and throats
IF you are planning on streaching the range out to longer prairie dog distance then maybe a 22-250,,,,
If I were going to go to a bigger gun,,for me a 243 would be the gun,,,it has a range of bullets that go from where the 223 and the 22-250 stop on up to the deer class bullets of 100gr+ range
is the 22-250 a better cartrige,,depends on what you are doing with it,,,in Ohio,,,I don't think so,,more muzzel blast,,more cost,,and like said earlier,, the pigs don't know if the bullet is running 3300,,or 3800,,he is DRT
This 223 I have has never failed to get the job done for me
thats my .02,,,YMMV
ocharry