I have pretty big hands... I find the Hogue monogrip to be an excellent grip for my Redhawk. When I get a S&W someday in .357, it will wear the exact same grips as the Ruger.
Oh, and wood rules. For anything up-to-and-including .44magnum, if you actually feel pain you're shooting wrong somehow. Grip angle, finger placement, something's not right if it actually hurts. Rubber is appropriate for supermagnum cartridges, but that's all.