I had a new model Colt .45 Series 70 1911 from the custom shop, and my major gripe right off the get-go was that those grip screws would begin backing out every time I'd put a box of ammo through it. I didn't want to put any locktight or chemical on the screws, so I took some on-line advice from someone which worked perfectly. I simply slipped a rubber O-ring around each screw like a washer (find the size which the screw barely fits through...I think they were #60s) and tightened them down. They never backed out again.