That refers to the particular frame size of Smith & Wesson revolvers.
J-frames are the smallest, followed by the K-frames, L-frames, and N-frames, which are the largest. Most of the frames are chambered in a wide variety of calibers.
J-frames are the small, 5-shot revolvers that are used by many for concealed carry.
The K-frames are most recognizable as the Model 19 .357 Mag. and the Model 10 in .38 Spl.
The L-frames are very similar to the K-frames, but are "beefier" in certain frame areas to better withstand the pounding of full-bore .357 Mag. ammo. Generally the L-frames are chambered for .357 Mag.
The N-frames are best represented by Dirty Harry's Model 29 in .44 Mag. "The most powerful handgun on earth... it will blow your head clean off..."
While these frame designations apply only to S&W revolvers, they're commonly known and accepted, and really form a basis for comparison with guns from other manufacturers.
For example...
Question: "How large is the 9T2792MHLH revolver from Blastemflats?"
Answer: "It's a little bit bigger than a Smith & Wesson K-frame..."