As a big fan of the .45 Super, I spoke with Gary Hindeman himself about this very topic.
He said that the .45 Super Tactical (A downloaded .45 Super which is essentially just a .45 +P+) is for guns like the Commander or Glock 30.
He said that no matter what you do, the Glock 30 and other small guns do not have enough slide mass to handle the cartridge, and it would never work reliably. He did not say it would blow up the gun or anything, but he said it would really beat up the gun (especially a small 1911) and it will never cycle right due to the lack of mass in the compact slide.
Those are words from the man himself, and I assume he has put a lot of time into testing this.
Go with a 10mm Glock 29 or just stick with .45 ACP +P which will do the job, if the job is human defense.
[This message has been edited by jdthaddeus (edited September 08, 2000).]