Under the conditions you've specified, it's difficult not to opt for the Python.
However, I go to the range a lot and believe continuous practice really does develop excellent proficiency. I also believe one should practice with his carry handguns. I'm not sure I'd want to use a Python in these ways (although it's clearly a personal choice, I'd want to "preserve" a Python), but I have not problem using either of my GP-100s (KGP-141s) frequently -- for range and for carry.