S&W Model 19 or Model 28, .357 Mag., 4", loaded with Golden Sabre 125-gr. JHP.
HK P7M13 or Beretta 92 9mm, loaded with Federal Hydrashok 124-gr. +P.
Occasionally a Model 1917 Smith & Wesson .45 Brazilian contract, loaded with 230-gr. FMJs.
Occasionally a EAA Witness in 10mm, loaded with 180-gr. Federal Classic JHPs.
The reason I switch out depends on what gun I've had to the range, whether my primary night-stand gun is in need of cleaning, etc.
Oh yeah, under the bed is a Smith & Wesson 3000 Police riot gun in 12 gauge, stoked with Winchester or Remington (can't remember which) No. 4 buckshot, with another 5 rounds of S&B 00 buck (12 pellets, not the normal 9) in the carrier on the buttstock.
The above are my Home Defense Guns.
For CCW, I normally carry an S&W 042 with 125-gr. Fed. Nyclad +Ps.
I also carry a 2.5" Model 19 loaded with the Golden Saber 125s in .357 Mag.
When I carry a semi-auto, which is rarely, it's normally an HK P7M13 or a Kahr K9, with Fed. Hydrashok 124-gr. +Ps.