Hello. In a full-sized revolver or for one not recoil-sensitive, I think that the full-house 125 gr JHP from Remington or Federal is tough to beat. A sort of mid-range loading is Remington's 125 gr Golden Saber: It averages 1151 ft/sec out of my S&W M27's 3 1/2" bbl. Best.
I like Winchester's 145gr Silvertip. It averages around 1220 from my 4" Python and will give me a bit more penetration that the 125 gr bullets without sacrificing expansion.