I posted something about this back in 07. I'll go look for it. I did an experiment w/ my 22-250. (not advocating 22 cal here) I shot a deer smak in the shoulder - I had some shoulder issues of my own, and got rid of my 300 win mag. I had that gun for elk hunting but got rid of it because I won't be going elk hunting anytime soon.
Anyway - I shot a 8 pt smack in the shoulder. It was a w/ a 55gr. Sierra Game King - thicker jacket than factory stock ammo. It was reloaded and shooting around 3680 fps. Anyway, Bang flop - imense hydrostatic shock - internals were blown to goo. (heart/lungs) But...no exit. Good thing I got a bang flop. Had the animal ran, tracking would have been downright impossible with no exit, and a small entrance wound. I killed 8 deer, and 3 hogs with that gun, the hogs being shot in the head. Shoulder is better now, Dad passed away, so I have spent some time working up loads and will take his 270 to the field this year, for sentimental reasons, as well as performance - I found myself in an undergunned situation - we were doing some hog management, and on our way out, there was a HUGE boar. I shot for the head, but I hit what I think was in the neck. We heard the bullet smack, andsaw a huge amount of dust fly off in that vacinity from the hog & it took off like nothing. Looking back, we theorized that hog was close to 400lbs. Way to thick a skin for that bullet. Had I had the 270 this would have been a dead animal.
The point is, I'd go with a bullet designed for the game you are shooting, take it up a notch for the unexpected. Down here, where I hunt, large oversize boars are around, and I want a bullet that is capable to take one down, especially if charged. Doesn't mean monster bullet, but for my 270, I'm going w/ the optimal 130 gr. BTSP. In your 25-06, Id go 100 gr or heavier, w/ my preference being 115-120's. I'm not a fan of partitions because of their exposed lead base. Bullet tests show that the base of the bullet has more dffect on accuracy than the tips. I reloaded 25-06 for years until I wore the barrel out of my 25-06. My guess is I ran over 5000 rounds through it. I shot it like I shoot my 22-250 today.