With a 180 grain bullet at 3100 fps, a +3.3" zero at 100 yards should put you close to dead on at 300 yards. At that, you'll be around 10" low at 400 yards, which is about as far as I'd shoot at an elk. They're tough if you don't hit 'em right.
A 200 yard zero would put you 1.3" high at 100 yards, about 6" low at 300, and 17" low at 400 yards.
You should know your area well enough to know what kind of range you'll likely shoot at, and you should sight in accordingly.
Daryl