A number of years ago, in Montana, I killed a nice spike elk at about 175/185 yards, with my .280 Rem., using my handloads, 160 gr. Nosler Partition, and 54 grs IMR4350. One round as he was standing and feeding, broadside, across a meadow.
Normally I use a .338, but the .280 is always in camp as a backup, should I need it. I wouldn't hesitate to use my .280.
J.B.