i load 45lc and 44-40, and i have no trouble with either. but from a standpoint of just going to a store and buying ammo, the 45lc is what i would get. but i do like the 44-40 and shoot it more. the cost of store bought 45lc and 44-40 is allfull, 50-60 dollars a box. you must reload to realy save money. i just bought 500 lead 200gr 44-40 bullets for 45.00, 500 primers cost 17.50 and a pound of imr 4227 cost 26.00. to load 500 rounds(10 boxes) cost, bullets 45.00,primers 17.50, powder 43.00 (useing 23grs) total cost 105.00 for 10 boxes plus your time, for the 45lc your bullets may be a little more but not much. eastbank.