Well...I like fat grips. Logically, that means that a single-stack (for me) is wasted space. I own two single-stack pistols (SW 4506 and a Sig P232). Both of them have optional fat grips on them and carry too few bullets for my liking. I understand that some people like narrow grips, and for them single stack is the way to go, but not for me.
And no, I don't have big hands...which is what surprized me. Someone, somewhere looked at my small, slender hands when I was a teenager and predicted that I'd dislike his Browning HP since it wouldn't fit comfortably in my grip.
Wrong.
BTW, I think that the ergonomics guy at S&W is a closet masochist. Extremely straight backstraps + narrow grips = discomfort. Just my $0.02
Mike
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"A human being should be able to change a diaper, plan an invasion, butcher a hog, conn a ship, design a building, write a sonnet, balance accounts, build a wall, set a bone, comfort the dying, take orders, give orders, cooperate, act alone, solve equations, analyze a new problem, pitch manure, program a computer, cook a tasty meal, fight efficiently, die gallantly. Specialization is for insects." -Robert Heinlein