I have a 550B as well.
A few years ago, with a little help of my overall positive results with my 550B, a coworker bought one also. During his startup in reloading, he had found that he was getting inconsistant powder charges particularly when loading larger calibers. This surprised me a bit as I had felt that I was getting pretty consistant results with mine.
In attempting to find a way that would cause a larger than normal variation (greater than ±0.1 grains), I tried many things. [First though, I reloaded a few rounds and checked powder variations. Nothing out of the ordinary was found.] I did eventually find a way to get a very large deviation. I had found that when the reloader was physically shook or banged on during the reloading process, more powder would fall into the powder throw bar (when it was in the position to pick up powder). An error of ±0.5 grains could be made, at least by me on my machine. IMO, I think that since the hole that the powder flows into is square (rectangle) it is impossible to fill every corner every time. When the reloader is shaken, more powder will fill these voids. Also, since I regularly use flake or disk powder, shaking the charge (without even considering the shape of the hole) would just align the particles better and allow more to be packed into a volume.
In short, the more unstable the platform and the more vibrations the machine is subjected to while reloading, the greater the error in powder charge.
This is what I found but it may not be exactly what you are encountering.