For me, handguns are predominantly self/home defense weapons. My Taurus Judge is on my nightstand for emergency use when I might not be as accurate. For similar purposes, I keep other handguns around the house - in .32, .38, .357, and 9mm calibers. I suppose I could use the Judge or the Python for hunting if it became absolutely necessary (or if I somehow get inadvertently stuck in a Walking Dead episode), but I've got long guns for that purpose.
So yes, my few handguns cover most of my needs.