I've been using 50gn Nosler BT's for prarie dogs and they blow the little beasties up out to about 400-450yds. As for HP's I used to use them back prior to the Nosler's and they usually worked, but not to as great a range. Would get occasional failures at 300yds or so. Depends on the weight, velocity and design. 69gn Sierra MatchKings would sometimes blow up the critters at close range, but more often zipped through without doing anything. Not unexpected. Would maybe work better on people if you hit bone or something solid, as opposed to lung tissue. Semper Fi...