Yes, for many of us - that own a variety of guns - having different triggers is an issue - and yes, I shoot some way better than others ...until I adapt in the range session to what I'm trying to do.
In my case ... I have a lot of S&W revolvers ...in 2", 3", 4", 6" and 8 3/8" barrels and in calibers of .22, .38, .357 mag and .44 mag ...and Sig Sauers in 239's and 226's in 9mm and .40S&W but all DA/SA triggers at least --- and a variety of 1911's in 9mm, .40S&W and .45 acp in 4" and 5" ...
Transitioning from one 1911 to another ( even an all stainless 5" gun in 9mm to a .45 acp in an all stainless 5" gun ) is real easy. I shoot them both very well. But if I switch to a 4" alloy frame gun in 9mm or .45acp it takes me 6 or 8 rounds to get the "feel" back... If I drop down to a 3" gun ...it takes more time ...especially in "rapid fire" on follow-up shots...
Same issues on revolvers ...weight, barrel length in .357 are pretty good - but going from a 2" to a 6" is a big jump / and even though triggers are all about the same - grips are different / so its still a transition... When I move up to the .44 mag ...the transition takes a few rounds ( especially in a 3" barrel mode .44 mag )
On my Sig's - the 239 (single stack) and the 226's double stack ...are way different / and it might take me 25 rounds to get it together .... Changing from one to the other in 9mm is pretty easy ...its tougher on .40 S&W ( especially in the small 239 model ).
If I were to mix in a Glock or Beretta ...or anything with a different set of controls and a way different trigger ...transition is even worse.
But having a lot of guns to shoot / collect is fun too ...
I do depend on my 1911's as my primary defense platform ...and I stay with a 5" gun for defense ..in .45 acp / so I focus my training there ...where most of the other guns I have and shoot ...are more for fun and variety ...and training the grandkids...and just because !! If I were just focusing on defensive training - whatever platform you decide is your best option ( ideally what you shoot the best ) is where you should focus your training ...and grip, and controls, and feel of triggers, etc ...so you get the most out of your training. But shooting just one gun / or one platform ...is a little boring...
I tend to take groups of guns to the range ...make it a 1911 day ( say three 1911's one in 9mm, one in .40S&W and one in .45 acp ../ or make it a revolver day - say all K frame S&W's a 4" in .22, a 4" in .357 mag and a 6" in .357 mag ...and stay with one holster ...and run thru my courses of fire ..and evaluate myself on each step --- getting out of holster on target, 1 shot on target ...then 2 shots on target ---then triple taps. Then 1 shot - reload - 1 shot ....then double taps with a reload ...then triple taps with a reload. I usually end each gun - with a 6 shot slow fire group at 30 feet ( until I can cover that 6 shots with a 50 cent piece ) - or work to that goal at least. Somedays I'm ok / someday's I'm pretty good ...and someday's I suck ...which means I get to go back to the range a few days later and work on cleaning it up !!