Well I purchased the first one back around '87 and figured I would shoot it a while then have it rechambered to the AI version. I had it in lay away for almost two months and had two boxes of shell loaded for it when it came out. At first I used some Sierra 117's since I had a friend who had given me some. They worked fine for breaking in the barrel and actually shot pretty decent.
After the break in I switched over to some Nosler 100gr BT,s and worked up probably the most accurate load I have ever shot through that rifle. It would easily stay around .375" at 200yds and still does. The draw back however was the BT running at 3350fps I found out, was a bit much for whitetails around here. I shot several does at ranges from about 50yds to around 350yds. Even at the longer ranges there seemed to be a bit more trimming than I wanted. So I backed off the load a tad and swapped over to the Partitions. I harvested the first buck for that rifle with them at about 40 paces. The bullet did a wonderful job and all was well. They shot almost as good as the BT's but I still wasn't happy.
I played with several other bullets and then a friend loaned me an older copy of the Nosler manual than I had, and in it I noticed that they had the 115gr Partition listed. Mine only had the 100's and 120's. So I began to look for them and ended up having to order 5 boxes from the rep. I went to work on them using several powders and found that RL-22 was the overall best. The end result was a load which was close enough to the initial 100gr BT load that I was happy, it leaves the muzzle at 3150fps, and groups around 1/2" at 200, and will still keep under an inch out to 300. I have used this load almost ever since. It has taken deer, hogs, yotes, skunks, and squirrels at ranges from almost burning the hair off to out past 400yds and nothing has gone more than a few yards from impact.
The thing about a good load in the 25 is that it allows precise shots to be taken. Granted some critters are tougher than others, but they all have to breath and get oxygen to the brain. I concentrated my shots on hitting the CNS and or the lungs all at once if possible. The damage done has been minimal on deer or hogs, but pretty explosive on the smaller stuff simply due to the velocity. The partitions hold up well and penetrate deep even on the tougher hogs.
Two years ago I passed that rifle over to my daughter. It was shortly after the 110gr Accubond came out that I swapped out one of them for one of the partitions one afternoon just to see how they shot. IT fell right in the middle of the group of partitions at 300yds. Same load used for both bullets gives 3250fps for the 110gr. So this is the bullet my daughter is now using and has taken several nice bucks with it, as well as a couple of hogs, and two yotes. All have dropped in similar fashion to the partition. Damage has been a bit more of a wider wound channel with the AB, but penetration is very similar.
All rifles are different but if I were to recommend a couple of bullets for all around use it would have to be them. If your more on a budget you might look at the Core Loct's or the Hornady line, and I do not think you would be disappointed.
Powders for the 100gr should be in the IMR-4350 to IMR-4831 burn rate, and for anything heavier the RL-17 - 22 or H-4831 area should get you all you could ask for. If you can find it I would suggest using Winchester cases, just from personal experience. Standard large rifle primers are all that should be needed. Pick which ever one works the best for you.
Good luck and hope this helps.