It might be awkward for a Lefty to own the Cz-82 as a carry gun which requires the safety with a chambered round, or one could try to remember to leave the chamber empty and rack the slide. Not adviseable...
Neither the CZ-82 nor the Makarov has a firing pin safety. (The Mak has passed California's drop safety tests some years back without it. I don't know about the CZ-82.)
The CZ-82 has an ambidextrous safety and mag release, but no decocker. If you have a chambered round and don't want to decock, THAT is when you use the safety.
With the CZ-82, when the safety has been used and is engaged, you can't pull the trigger. If you engaged the safety with the hammer cocked, releasing the safety allows you to use a lighter Single Action trigger.
With the Makarov, using the safety lever decocks the and you CAN pull the trigger, but it's the longer, heavier Double Action trigger. (The safeties work quite differently; the safety for the Mak is really a decocker.) As noted above, neither gun has a firing pin safety, so using the safety lever for either gun dos nothing to prevent an "inertial" discharge if the gun is struck or dropped -- but it may be a non-issue with the Makarov.
I've owned both. (My Makarov was an East German Makarov made in Suhl, considered one of the better Makarovs.) I found the CZ a bit more pleasant to shoot, and liked the fact that it had 50% more rounds (and extra 4!) The Mak is an elegantly simple design, sophisticated in it's own way. The CZ-82 is a bit more complex, but functionally a more sophisticated weapon.
The CZ-82 is available ONLY in 9x18 (9mm Makarov), but the CZ-83, basically the same gun as the CZ-82 was made for commercial release, and can be found in 32 acp, .380 and 9x18 makarov. The Makarov was only made in 9x18. The few Bulgarian Maks I've seen seemed to be pretty nice.
Both are excellent guns and considered among the best of their type.