It depends a lot on a lot of things, but I have seen 50 fps loss stated with .006-007" gap. That is not insignificant, but not really a lot in an adequate load.
Most tests are x gap vs. no gap, but "no gap" in a revolver is impossible*, and any gap under .003"-004" can result in cylinder binding when the gun heats up from firing.
*OK, OK, I know about the Russian Nagant, so anyone who carries one can get a bit better performance. I also know about the Savage percussion revolver; anyone who carries one of those is lopsided.
Jim