I have taken my handgun swimming twice (inadvertently both times, while on my boat).
Each time, I took the gun home, removed the ammo, cleaned and re-lubed the gun and put the ammo aside for the next range trip. All the ammo fired normally.
If ammo will survive submersion without water getting inside, I can't imagine humidity getting inside.
People's opinion on how frequently to fire one's carry ammo varies. Some say every month, some say every two years...honestly, I wouldn't be overly concerned about it.
I have shot surplus ammo that is 50+ years old without problems. Note that I am not advocating that you keep your carry ammo for 50 years....just that I wouldn't stress too much over it.
The repeated loading/unloading resulting in setback (as mentioned above) can be an issue, so I would be aware of that.
As far as repeated chambering affecting the priming compound...that is a new one on me. And I'd have to see some evidence supporting that claim before I would consider it seriously.