I have them on three handguns (S&W 637 Airweight, 686+ and Browning Hi-Power), so you may call me sold on them. I shoot the 686+ and Hi-Power on a weekly basis at my range, fifty rounds each. I just love to see a black hole appear in the target where a red dot used to be! I usually shoot five - ten rounds with iron sights, just to prove to myself I am still, at seventy-nine, a good shot with them. But since I cannot even SEE the iron sights without my glasses on, I concentrate on what I need a handgun for: SD/HD.
I would not recommend red laser sights for bowling pin busting at fifty yards in the noonday sun. For that, iron sights still shine.
Cordially, Jack