I wouldn't hesitate to use "hot" ammo in any quality firearm on an occasional basis. I wouldn't feed a steady diet of +p ammo to a gun that I wasn't sure of, but I don't see the harm in putting an occasional cylinder full of +p's through one. Any S&W that is in good working order with no stress cracks, a properly locking and aligned cylinder, and a forcing cone in good condition should be fine for this.