Yup, it's exactly what the doc ordered for self defense in your beastie. VERY effective self defense.
There are several similar rounds out there, made to operate at around 18,000 - 20,000psi. That way, you can use 'em in something like an Italian SAA safely...in your 454 they'll all be pussycats as far as recoil is concerned. That Cor-Bon load is one, another is the Winchester Silvertip .45LC, and Pro-Load has something in the same class. I have no solid clue which is better, the Pro-Load or Cor-Bon at present. Cor-bon should start loading the 165grain or 200grain Pow'R'Ball projectiles in the .45LC cases sometime soon, at which point that'll probably be the ultimate king of the hill defense load in your gun. The Pow'R'Ball is "a generation past the usual JHP" in that it can't clog on clothes - right now they've reserved 'em for their semi-auto calibers first but they promise to completely replace JHPs with 'em in as much of their defense-grade product as possible...and since .45ACP and .45LC take the same bore, .45LC should be the first of the Cor-Bon wheelgun calibers to get the Pow'R'Ball.
Until then, the Gold Dot projectile as used by Pro-Load might have a slight edge over Cor-Bon. Note the words "might" and "slight".