I find it somewhat ironic that the type of recoil assembly used on the Colt Defender (and many other compact 1911s from various manufacturers) was widely hailed as a big improvement over a standard guide rod and recoil spring when the new type assemblies were introduced. Now we're looking to go back to a variation on the old system, and that's being touted as an improvement ... on the improvement.
The flat-wire spring is a worthwhile innovation, more than a "single" spring, per se.
I've done some swapping of conventional single, dual, triple, and single flat-wire recoil springs in a compact .45, and I was impressed by the additional in-battery pressure applied to the barrel/slide by the flat-wire.
With a single, round-wire spring, the spring is almost fully relaxed when the gun is in battery, with very little pressure actually holding the gun in battery, and very little resistance to initial slide movement in recoil.
Increasing the number of springs increases the resistance, but I think there's always the sense that adding parts increases the likelihood of parts failure.
I'm running a triple-spring set-up now, no issues, but I think a single, flat-wire spring would be an improvement, if only due to simplicity.
A single, round-wire recoil spring, in a compact .45, would be last on my list.