Depends where you live but Id go for 45-70 or .270, the .270 is good on more open areas out west due to its extremely flat trajectory and if loaded properly hits with just as much power as a 30-06. The 45-70 is good out to shorter distances but will most likely cause more damage, especially these days with hard cast loads, I read about this guy hunting water buffalo in africa which are one hell of a creature. One guy went for a heart shot and broke both of its shoulder blades and it was DTR, the other one was a frontal shot, it went all the way from its chest to its pelvic area supposedly, definatly dont under estimate a cartridge like that.