yup
I run #4B through a 12 ga. Rem Turkey super full (the tight one with the knurling). It leads the tube heavily, and I'm not so sure that a conventional full might not do better pattern wise. Those big pellets are likely getting mashed heavily.
But in the areas where I use the shotgun on coyotes, shots are not that far and it works great. I think #4B is a great killer on coyotes and similar varmints and pests inside 50 yds.