Bushog57, it's all trial and error, but that's also what makes reloading fun. Check out the Hodgdon Reloading Data site. For the Nosler 150gr Bal Tip you'll find 21 loads, using 21 different powders. I generally look for the powder that gives the highest velocity at maximum load, but the lowest pressure. Some pressures are listed as PSI, others as CUP - you cannot equate these, so just stick with those that have the same pressure indicators to start.
For example, I chose Superformance because maximum load gives 3072 fps with 53,000 PSI. Compare that to IMR4451 (2969 fps/59,700 psi) or IMR4350 (2942 fps/57,200psi).
The max load listed for Superformance is 65.0gr. I have repeatedly read that one should start 10% under max, but I think that is a lot of powder wasted as you climb to the max. After 40 years I found I can start with my max 1 grain less than that listed (e.g., 64.0 gr), but I'll make 3 loads of 3 cartridges each: 64.0gr, 63.0gr and 62.0gr.
I'll shoot the lowest first and watch for pressure signs as I get to the highest load. Only once did I lock up a bolt doing this in my 7mm Rem Mag with a 110gr TNT bullet. (I've loaded .22-250, .223, .222, 6mm PPC, .243, .25-06, .257 Roberts, .270 Win, .270 win Mag, 7mm Rem Mag, 7mmSTW, 30-06, .308 Win, 300 Win Mag and .338 Win).
If I don't get a good group that way, I'll change bullets and start over again.
You will find, quite often, the best accuracy is not necessarily at the highest velocity. If you get one group that stands out but is not quite 1-MOA, then play with increments: e.g., if 63.0gr is better than the other 2, try 62.5gr or 63.5gr. But there are other variables as well: do you seat your bullets as listed in the manuals (Overall Length) or do you seat them some distance from the rifling ("leade")? It can get complicated, but just keep your plans clear and avoid frustration. Good luck!