First, I was thinking of top breaks made for .45 ACP and .45 AR, not guns converted to use those cartridges, so my bad on that.
There are two basic limitations in top breaks. The first is that they won't handle high pressure cartridges for any length of time and they won't handle long cartridges without sacrifice of the automatic ejection feature.
If you use/make a strong top break (like the NM No. 3) for something like the .44 Russian, you would probably be able to shoot it indefinitely. But, as I said at the beginning, most folks consider cartridges at that pressure level inadequate for practical use today. That means that a new gun in .44 Russian, say, wouldn't sell. (.45 Colt has a separate problem in top breaks, the small rim giving extraction problems, as it did in the Schofield; the Colt SAA, with a rod ejector, had no problems, of course.)
Jim