HiBC and scott1119 -
Thank you for the help.
The screw is the retaining screw for a Single-Six ejector rod housing, so the hole is tapped in the barrel. I removed the screw and ejector housing, but, due to factory Loctite (I assume), the screw will not thread into the hole (I checked prior to attempting to install the housing).
I may first try the nail polish remover, if it won't harm the bluing. If I can find a tap that size with a flat tip (since the hole is so shallow), I'll try to clear the threads.
I tried a screw from another S-S, and it would not thread into the hole, either, but I'll probably call Brownell's or Ruger and order a new one.
I realize that the screw itself doesn't carry much load, but the amount of threads that engage is minimal anyway, and I don't want to damage the barrel.
Thanks again -
Monty