Wow, you can fit a lot of guns between those two. Between a Glock and a Sig I'm always going to have to insert my Detonics Combat Master. Even though it's 32 ounces empty it is 100% Stainless and now that I've solved a couple of magazine issues, very very reliable. I'm carrying it as my EDC and trust it completely. Can't beat the 1911 design. There, did I hijack the choices enough?
I tried the p250, and like others told me on here, the trigger reset is really really terrible. I like the pull a lot, but to get the trigger to reset, you have to have to let it out nearly all the way.
Welcome 33raven Im a Glock fan myself but both your choices are good ones Iwould say the one fits your hand the best because both you can bet on good luck.