I hunt Utah and Idaho. We regularly get mule deer well over 200 pounds, a 300 pound buck is not uncommon. That said, I know many people who have killed deer humanely and quickly with small stuff, they are also good shots and dont take questionable shots. My buddy's mom used nothing but a mini-14 for years and killed numerous deer, antelope and a few elk. She used 55 grain softpoints and only had one animal that took two shots, it was an antelope. She knew the guns limitations and her own. I have seen deer run off after being hit with 300 mags, found some and some were never seen again. I watched a neighbor shoot a cow elk in the but right in the top of the pelvis between both hips with a 300 ultra mag. That cow was found, 2 days and over a mile later, it was his first year with that gun and he was scared of it because of the recoil. If you know what your rifle can or cannot do and stick to those limitations as well as your own it really doesn't matter if your shooting a 338 or a 218 bee, dead is dead and wounded sucks. I use a 270 win. and have been extremely happy with it, but I don't think there is a perfect caliber for everyone in every place, use what you like and use it well, the game will never know or care that it wasn't a 577 tyranosaur.