The Smith & Wesson Model 25-5 chambered for the .45 Colt is a fine gun and one I pack daily myself. The problem with the Smith &Wesson guns in general is not so much a strength factor but rather a design factor. Before you S&W people beat up on me please listen. It has long been evident that the Model 29 in .44 Magnum very quickly beats itself apart with full-power loads. This is not technically a "strength" problem as much as a design problem and the assemblage of several small parts that are not as rugged as the Single Action design. In the course of time if all the little parts wear a tiny bit this soon adds up to a lot of play in the overall fit and lock-up of the gun. This in turn allows the gun to get a further "run" at itself under discharge and thus hastens the battering process. In reality the Model 25-5 is about 80% as strong as the Model 29 in the cylinder area. The frames are the same and are designed for a 40,000 psi load level even though we know this is a bit more than they are happy with. It's too bad S&W built a 40,00 psi cylinder and installed it in a 30,000 psi frame, so to speak. (note: since this writing S&W has worked on the problem of the cylinder unlatching and rolling back under recoil after it gets a bit worn) The 25-5 in .45 Colt is safe to 80% of the 40,000 psi of the .44 Magnum Model 29. This allows a load of 32,000 psi in this frame. I have shot hundreds of the 32,000 psi class loads listed at the beginning of this article in several Model 25-5's. Recoil is heavy due to the S&W "hump" on the grip, but I do not see these loads as being dangerous in this fine gun. I do consider 32,000 to be ABSOLUTE MAXIMUM for this gun and prefer to hold my personal loads to 5% under those listed loads for approximately 25,000 psi. I carry a S&W 4" in .45 Colt daily and shoot a 260 gr. Keith at 900 fps for general duty. When I saddle up and go into the hills I pack the same gun with a 310 gr. NEI Keith over 23 gr. H-110. This gives me about 1080 fps and all the punch I need for anything on our mountain. As with any gun and load data, work up carefully. I assume responsibility only for the ammo I myself assemble.