The hotter the round, the more stress on the forcing cone.
I was (and still am) using a 686 for match shooting, using relatively mild .38spls and plated bullets. My first 686 was remarkably accurate, but noted it's fine accuracy degraded a tad around the 60,000 round mark. Because of the mild loads, the forcing cone is fine, as far as I can tell. Timing is still good, as is the crown, so my suspicion is that the rifling simply wore some.
It's now got about 70,000 rounds through it, and is my backup gun. It's still capable of good accuracy, and because I'm so familiar with it, it's likely only I'd be able to notice the slight loss of accuracy.
Bottom line is what others have offered - if you're not going to feed it a steady diet of hot ammo, the barrel ought to last many tens of thousands of rounds. Exclusively fed target wadcutters, my WAG is that you could expect a barrel life of over 100k rounds.
Is there any additional wear in cylinder chambers due to reason of continuous firing shorter cartridges (38 sp WC) in 357 cal?
No. But get the habit of regularly cleaning the chambers. You won't need to go to heroic lengths to clean the chambers if you do it regularly. Don't rely on shooting .357mags to "clean out the .38spl carbon ring". I'm betting it's an internet tale, not particularly effective, and not particularly good for the cylinder.