While I have no experience popping my .40 off at any critters, I've still carried it before when I'm in places with animals that can hurt me and I'm not bringing a shotgun or rifle. That said, I've heard it's fairly ineffective against game compared to the .357 mag. If you read recommendations for bear defense, the .357 mag is usually the recommended minimum, with the popular defense cartridges (including the .40) usually being discouraged. That said, I'm pretty much nothing, and I'm not necessarily saying the opinions I've heard and read are experts, but the vibe I've gotten is people usually opt for a magnum round. Not that I even need it - don't live in "real" bear country, they only occasionally wander into the vicinity of my family's cabin, I've yet to see one there - but I'm still looking to get a .44 magnum for a game gun. In the case of bobcat, flaked out coyote or rabid racoon, I certainly think the .40 would suffice, but I'd rather just go with one of the "established" game rounds rather than something which has pretty much only been mused on for human targets. I did hear a story once about a guy bringing down a deer with his .40 S&W - 9 shots. Doesn't seem like ethical hunting to me.