Run what works in your rifle.
Generally, it's a good idea to start with data listed as semi-auto data, though.
Sometimes you'll find it labeled as something like ".223/5.56 Service Rifle" or ".223 Remington (Semi-Auto)" or "5.56x45mm AR-15".
You do need to approach it a little differently than loading for a bolt action. In a bolt gun, if it goes bang and isn't over pressure, all you need to worry about is group size (or some other down-range performance metric).
But in a gas gun, you have to find a load that cycles the action properly, while also giving acceptable results down-range.
In my experience, most people that aren't chasing maximum velocity end up with pretty sedate loads in ARs chambered for .223/5.56 (or a cartridge based on them). Most of my family, for example, has independently ended up with loads that are much like my own: Mediocre velocity and estimated chamber pressure of just 44k to 48k psi.
Use what works in the rifle.