I've killed 2 bucks in 2 years with my .300 BLK.
Last year an 8 point @100 yards. He ran about 15 yards after taking one high in the lungs. Never lost sight of him. Lungs liquefied.
This year a 7 point #about 70 yards. He dropped where he was shot. Hit him perfectly, top of heart arteries GONE. Lungs pretty much mangled too.
Bullet went completely through in both cases so no recovery. Exit holes almost golf ball sized
Using 125gr Nosler BT's about 17.0 grains H-110 If I remember correctly(I'd have to check my load notes to give you an exact powder weight) Muzzle velocity about 2100. Way over sub sonic. no suppressor...yet